Genomic Ranges
- Intervals of DNA sequence within a genome that can range from a few nucleotides to entire chromosomes.
- Used to focus genomic analyses on features such as genes and promoters.
- Enable identification of genetic variations that may affect gene expression or disease risk.
Definition
Section titled “Definition”Genomic ranges are specific segments of DNA sequence within a genome. These ranges can vary in size, from small sections of a few nucleotides to larger regions encompassing multiple genes or even entire chromosomes. Genomic ranges are used in genomic studies to identify specific genetic elements or to analyze the expression of particular genes.
Explanation
Section titled “Explanation”Genomic ranges designate precise locations in a genome so researchers can concentrate analyses on defined DNA intervals. By delimiting the boundaries of genes, promoters, or other elements, genomic ranges allow more precise examination of genetic elements and their expression. Studying these ranges helps researchers detect genetic variations within those intervals and assess their potential roles in disease or other biological outcomes.
Examples
Section titled “Examples”Gene (BRCA1)
Section titled “Gene (BRCA1)”A gene is a section of DNA that codes for a specific protein or functional RNA molecule and is located within a specific genomic range. For example, the BRCA1 gene is associated with an increased risk of breast and ovarian cancer. By studying the genomic range of the BRCA1 gene, researchers can identify genetic variations that may increase an individual’s risk for these diseases.
Promoter (HIF1A)
Section titled “Promoter (HIF1A)”A promoter is a region of DNA that controls the expression of a gene and is located upstream of that gene. Promoter regions can vary in size. The promoter region of the HIF1A gene has been shown to be associated with the development of certain types of cancer. By studying the genomic range of the HIF1A promoter, researchers can identify genetic variations that may increase an individual’s risk for these diseases.
Use cases
Section titled “Use cases”- Identifying specific genetic elements (for example, genes or promoters).
- Analyzing the expression of particular genes by focusing on their genomic intervals.
- Enabling more precise analysis of genetic elements to understand their roles in disease and other health conditions.
Related terms
Section titled “Related terms”- Gene
- Promoter
- DNA sequence
- Genome
- Expression